A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 Quantitative Proteomics Reveals Significant Downregulation of Glutathione Metabolism in Sepsis Induced Liver Injury Journal of Proteome Research Downregulation of Glutathione Biosynthesis Contributes to Oxidative Stress and Liver Dysfunction in Acute Kidney Injury Shang 2016 Oxidative Medicine and Cellular Longevity Wiley Online Library Lipid Peroxidation in Hepatic Fibrosis IntechOpen
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