Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted Activation of neurogenesis improves amyloid pathology and cognitive function through AMP kinase signaling in Alzheimer's disease model mice ScienceDirect Modifying Factors of Adult Hippocampal Neurogenesis: A Dorsoventral Perspective in Health and Disease[v1] Preprints.org Reduced neurogenesis in human hippocampus with Alzheimer's disease Cao 2024 Brain Pathology Wiley Online Library
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