Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Glutathione is a critical soldier in our line of defense. We even have mechanisms that recycle and reuse it. But what happens when our toxic burden becomes too high? Our genetic detoxification Glutathione Mediated Redox Regulation of Immune Dysfunction in COVID 19 and Tuberculosis A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010