GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY When Good Drugs Go Bad: Acetaminophen Toxicity tl;dr pharmacy 3 (glutathion S yl)acetaminophen C18H24N4O8S CID 83998 PubChem Acetaminophen & the kidney Renal Fellow Network
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glutathione and acetaminophen g-glutamyl cycle. Depletion of glutathione by acetaminophen leads to