Effect of Melanotan II on sexual desire a Download Table Melanotan 1 (MT1) Therapy: Realistic Results and Expectations An oral melanotic macule is a harmless dark spot found on the lip, most often the lower lip, or inside the mouth, either on the gums, inside the cheek, or on the roof of the mouth. An oral melanotic 30 year old man with painless hyperpigmentation on buccal mucosa of a few months duration. Relatively stable in terms of size. Mirror lesion on other cheek. No history of trauma or smoking.