paracetmol poisoning 160215161539 (1).pdf Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Oxidative stress mediates end organ damage in a novel model of acetaminophen toxicity in Drosophila Scientific Reports View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine