Frontiers Paracetamol Induced Glutathione Consumption: Is There a Link With Severe COVID 19 Illness? How Heavy Metals Worsen Neuroinflammation and Mast Cell Dysfunction Interplay of oxidative stress and neuroinflammation in alzheimer's: insights into age driven pathogenesis Inflammopharmacology Springer Nature Link Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione.