Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Acetaminophen (brand name Tylenol) is found in hundreds of prescription and over the counter medicines. Taking more than directed can cause serious health problems. Always read medicine labels and follow the instructions carefully. If OTC, NOT RISK FREE: We're getting more calls than usual about acetaminophen, the active ingredient in Tylenol. Many over the counter (OTC) products contain a mix of pain and fever reducers, cough suppressants, and other Anion Gap Acidosis Associated with Acetaminophen Annals of Internal Medicine