Do You Reach for Tylenol Often? Whether it's for pain, headaches, or fever Tylenol (acetaminophen) is one of the most commonly used medications. But here's something most people don't realize Codeage Liposomal Glutathione, Phospholipid, Non GMO Sunflower Oil Glutathione: The Master Antioxidant Core Med Science Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.