Glycolysis as a Red Blood cell Metabolic pathway Glucose 6 phosphate dehydrogenase (G6PD) deficiency X linked recessive Xq28 is not true recessive as heterozygotes can express the trait; G6PD > No NADPH > No RBC glutathione protection > free radical damage hemolysis Elevated glutathione levels may reflect an accumulation resulting from impaired recycling, often due to deficiencies in NADPH, selenium, or riboflavin (vitamin B2). This indicates a disruption in the redox balance rather than Disorder of Glutathione Metabolism Springer Nature Link