I thought this would be an impossible case. Sara has a health condition that requires a Vitamin B12 injection every 3 weeksa tough challenge for acne prone skin, as B12 is notorious for Is B12 making you break out? It's possible. We've found in our own experience and in clinical studies that certain forms of vitamin B12 can trigger inflammatory acne for some individuals. Taking Vitamin B12? Read this first. While B12 is often hailed as a safe energy and brain booster, many real users are reporting unexpected side effects including anxiety, insomnia, Did you know that B12 supplements can significantly contribute to acne? , Ive seen it time and time again with my clientsmany experience stubborn breakouts that clear up once they stop