Acetaminophen and aspirin toxicity are both high yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is N acetylcysteine, which S Acetyl Glutathione Supplement Which analgesic causes liver toxicity? Implications of Altered Glutathione Metabolism in Aspirin Induced Oxidative Stress and Mitochondrial Dysfunction in HepG2 Cells PLOS One