Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity New England Journal of Medicine cagrilintide In the REDEFINE 1 phase 3a trial, semaglutide at a dose of 2.4 mg with cagrilintide at a dose of 2.4 mg led to significant body weight reduction in adults without diabetes and In the REDEFINE 2 phase 3a trial involving adults with obesity and diabetes, the use of cagrilintidesemaglutide resulted in a significantly lower body weight than placebo at 68 weeks. Full trial results
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cagrilintide and semaglutide 2.4 mg Another win for brain-centric obesity treatment approaches. Adding cagrilintide (an amylin analog) to semaglutide (a GLP-1 analog) enhances weight loss. 17.1% weight loss over 20 wk at highest dose, with weight still