Labial Lentigo (labial melanotic macule) Cancer Therapy Advisor Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Definition of melanocytic macules associated with Peutz Jeghers syndrome NCI Dictionary of Genetics Terms NCI Pigmented lesions of the oral mucosa and perioral tissues: a flow chart for the diagnosis and some recommendations for the management ScienceDirect