High homocysteine doesn't usually cause symptoms on its own, but it can signal vitamin deficiencies or other health issues and it's something you can check with a simple blood test Fitting homocysteine to disease models, as well as adjusting the models to the disease Journal of Molecular Medicine Springer Nature Link Homocysteine is an amino acid. Vitamins B12, B6 and folate break down homocysteine to create other chemicals your body needs. High homocysteine levels may mean you have a vitamin deficiency. With a Amazon.com: Allergy Research Group Homocysteine Plus Supplement with Setria Glutathione, Vitamin B Complex, Trimethylglycine, Vegetarian Capsules 90 Count : Health & Household