Labial lentigines, also called labial melanotic macules, is a benign skin condition that is more common in individuals with darker skin. They most often appear during adulthood although they can develop at Oral Melanotic Macule: Symptoms and Treatment Skinsight Pigmented Oral Lesions: Clues to Identifying the Potentially Malignant Consultant360 This patient has multiple labial melanotic macules. These are essentially freckles of the lips. These most commonly involve the lower lip. This patient had involvement of both the upper and lower lips.