Pigmented Lesions of the Oral Cavity Oral and Maxillofacial Surgery Clinics Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule. Is focal melanotic lesion potentially malignant? A case report ScienceDirect Teen Boys and Young Men Are Injecting Peptides in Search of Perfection WSJ