B12 Injections at Allura Skin, Laser & Wellness Clinic Do B12 shots actually work? Short answer YESfor the right people. Benefits may include: Increased energy Better focus Improved metabolism Especially helpful if you're deficient. If How to Give a B12 Injection: Step By Step Instructions Vitamin B12 is essential for energy production, nervous system function, and red blood cell formation. However, oral B12 supplementation doesn't work well for everyoneabsorption can be limited by digestive issues, certain medications,