Dr. Laura E. Riley joined @GoodMorningAmerica recently to clear up some lingering confusion about Tylenol (acetaminophen) use during pregnancy. A new study from the University of London found that acetaminophen is safe Downregulation of Glutathione Mediated Detoxification Capacity by Binge Drinking Aggravates Acetaminophen Induced Liver Injury through IRE1 ER Stress Signaling Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Sex differences in glutathione metabolism and acetaminophen toxicity