Is B12 making you break out? It's possible. We've found in our own experience and in clinical studies that certain forms of vitamin B12 can trigger inflammatory acne for some individuals. Breakouts from Vitamin B12 are some of the most common I see, even in longtime clients who are using excellent skin products and otherwise have their acne under control. , B12 causes inflamed acne and Is your B12 supplement causing your breakouts? It sounds like a paradox: you take vitamins to be healthy, but your skin starts acting up. While Vitamin B12 is essential for your Too Much Vitamin B12: Risks, Symptoms and When to Seek Help Bolt Pharmacy