Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Glutathione is a natural antioxidant your body makes, and it can influence melanin production which is why its sometimes marketed for skin brightening., Oral supplements are mostly broken down in Glutathione ? .. Dr. Karishma Abraham George Glutathione IV Infusions in Des Plaines, IL Skin Brightening