Glucose 6 phosphatase dehydrogenase (G6PD) and neurodegenerative disorders: Mapping diagnostic and therapeutic opportunities ScienceDirect Glucose 6 Phosphate Dehydrogenase Deficiency Hematology & Oncology UWorld Medical Library Although G6PD deficiency, which can cause problems in red blood cells upon certain triggers, is the most common human enzyme defect, affecting over 400 million people, including over 1 in 10 Black G6PD Deficiency Glucose 6 phosphate dehydrogenase deficiency X linked recessive disorder Leads to low NADPH, impairing glutathione regeneration RBCs are vulnerable to oxidative damage Pathophysiology: In G6PD deficiency: No