Frontiers Natural compounds in the management of polycystic ovary syndrome: a comprehensive review of hormonal regulation and therapeutic potential PCOS is complex but the right supplements can truly make a difference. When it comes to managing PCOS naturally, three supplements stand out for their science backed benefits: 1) Berberine often compared PCOS is complex but the right supplements can truly make a difference. When it comes to managing PCOS naturally, three supplements stand out for their science backed benefits: 1) Berberine often compared Acetyl l Carnitine Ameliorates Metabolic and Endocrine Alterations in Women with PCOS: A Double Blind Randomized Clinical Trial Advances in Therapy Springer Nature Link