Cagrilintide Peptide Therapy: A New Era in Appetite Control and Weight Revolution Health & Wellness Cagrilintide lowers bodyweight through brain amylin receptors 1 and 3 eBioMedicine Semaglutide, a glucagon like peptide 1 (GLP 1) receptor agonist, has well established weight loss benefits. Cagrilintide, a long acting analogue of the satiety hormone amylin, has shown promise for weight loss in early trials. The potential benefit Once weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double blind, placebo controlled and active controlled, dose finding phase 2 trial ScienceDirect