The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy Liver injury induced by paracetamol and challenges associated with intentional and unintentional use Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.