Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted Direct and indirect neurogenesis generate a mosaic of distinct glutamatergic projection neuron types in cerebral cortex ScienceDirect Small Molecule AngIV based Analogs to Treat Alzheimers Disease Growth factors and their peptide mimetics for treatment of traumatic brain injury ScienceDirect