Roles of Oxidative Stress and Nrf2 Signaling in Pathogenic and Non Pathogenic Cells: A Possible General Mechanism of Resistance to Therapy Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2 Expressing Glia Potently Protects Neurons from Oxidative Stress Journal of Neuroscience Sulforaphane boosts our natural cellular defenses. It does this by activating Nrf2, our body's primary detoxification, anti inflammatory, and antioxidant pathway. Nrf2 turns on phase 2 detoxification enzymes, helping us deal with daily Sulforaphane for Liver Health Sulforaphane is a food derived compound with a few core mechanisms. Nrf2 Activation for Phase II support being the primary mechanism. Increased glutathione production Increased phase II enzymes (GST,