5 Oxoprolinuria as a Cause for Metabolic Acidosis Renal Fellow Network Since Tylenol is such a hot topic right now, did you know it depletes glutathione levels? When your body processes Tylenol in the liver, one of the pathways creates a toxic byproduct. To neutralize The Metabolism of Acetaminophen and the Synthesis of Glutathione Download Scientific Diagram Acetaminophen Pathway (toxic doses), Pharmacokinetics