Acetaminophen detoxification in cucumber plants via induction of glutathione S transferases ScienceDirect Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. How can I minimize liver damage while taking Tylenol (acetaminophen) in relation to glutathione levels? Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors