The Influence of Intracellular Glutathione Levels on the Induction of Nrf2 Mediated Gene Expression by Dicarbonyl Precursors of Advanced Glycation End Products What is glutathione? Know as the most important antioxidant in the body, glutathione is an essential antioxidant manufactured in all cells, but primarily in the liver. It is essential because it Figure 2. The effects of hydrogenized water on intracellular glutathione (GSH) levels in human SH SY5Y neuroblastoma cells. The cells were treated with a series of culture media containing various concentrations of hydrogenized Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis Cell Death & Disease