Homocysteine: The Hidden Risk Factor Many Doctors Miss The School of Applied Functional Medicine When people think about detox, they usually think about the liver. But detoxification actually involves several systems working together. One of the most important is methylation. Methylation supports processes involved in MTHFR and glutathione's role in detoxification and methylation Estrogen Metabolism, Detoxification, and Methylation Dr. Daniel Metzger, DACM, L.Ac.