Glucose 6 phosphate dehydrogenase deficiency Knowledge @ AMBOSS File:Pathology of G6PD deficiency.png Wikimedia Commons File:Glutathion metabolism DE state in G6PD deficiency.png Wikimedia Commons Pentose Phosphate Pathway made simple. This pathway has two major jobs: Generate NADPH Produce ribose 5 phosphate NADPH protects cells from oxidative stress and supports fatty acid, cholesterol, steroid, nitric oxide, and respiratory burst