Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Oxidative stress mediates end organ damage in a novel model of acetaminophen toxicity in Drosophila Scientific Reports Efficacy of Oral N Acetylcysteine in the Treatment of Acetaminophen Overdose New England Journal of Medicine Do you have questions about the use of Tylenol during pregnancy? We spoke with Dr. Janine Hutson, maternal fetal medicine specialist and OBGYN about what the latest research says, what to consider and