3.2. Transport of glutamine and glutamate across the blood brain barrier Hyperammonaemia The distance between a compound demonstrating efficacy in preclinical research and that compound appearing in a physician's standard toolkit can span a generation. The mechanisms by which NAC addresses oxidative stress, glutamate Increasing blood brain barrier permeability with Acoustic Cluster Therapy (ACT) to enhance drug delivery in the brain Alanine and glutathione targeting of dopamine or ibuprofen coupled polypeptide nanocarriers increases both crossing and protective effects on a bloodbrain barrier model Fluids and Barriers of the CNS Springer Nature Link