Glutathione depletion and dual model oxygen balance disruption for photodynamic therapy enhancement ScienceDirect Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Highly Selective and Prolonged Depletion of Mitochondrial Glutathione in Astrocytes Markedly Increases Sensitivity to Peroxynitrite Journal of Neuroscience Frontiers Deuterium trafficking, mitochondrial dysfunction, copper homeostasis, and neurodegenerative disease