transsulfuration pathway of homocysteine metabolismRat Genome Database Homocysteine is an amino acid that requires efficient clearance to prevent vascular damage. High homocysteine levels can damage blood vessels and increase the risk of heart problems, especially in vascular EDS, where Transsulfuration pathway: a targeting neuromodulator in Parkinson’s disease Disruption of the transsulfuration pathway as a sulfur driven etiology of insulin resistance: proinsulin misfolding, disulfide bond deformation, and PDI dysregulation