Parents ask me this all the time: Motrin or Tylenol for fever? Here's my pediatric naturopathic perspective: Motrin treats inflammation, which often drives fever It lasts longer, so fewer doses sagesteele @P_McCulloughMD While I dont know whether there is a connection between Tylenol and autism, I do believe that there is reason to STOP giving it to babies children. Glutathione is impacted by Acetaminophen Toxicity Poisoning Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.