Solved Can someone please explain the pentose phosphate Chegg.com Frontiers The Role of the Pentose Phosphate Pathway in Diabetes and Cancer Explain how Inactivity or absence of Glucose 6 phosphate dehydrogenase ; a rate limiting enzyme in the Pentose phosphate pathway could lead to oxidative stress.* Glucose metabolism begins with its transport into cells via GLUT transporters, where it is phosphorylated to glucose 6 phosphate (Glucose 6 P). This molecule can enter various pathways, including the pentose phosphate pathway or hexosamine biosynthesis.