Not feeling well? *Don't* reach for Tylenol! Here are 8 reasons why. Some experts maintain that if acetaminophen were a brand new drug up for approval today, it would *not* get approved at Dr. Tylenol (acetaminophen) is not something I use or give my children or recommend for pregnant women. It depletes glutathione, an extremely important antioxidant and detoxification agent in the human body. Glutathione or L Glutathione: What is Better for Skin? Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect