Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted Hepatocyte Growth Factor MET Activator Rescues Working Memory Deficits after Repeated Mild Traumatic Brain Injury Katelyn A. Martino, Arush Nakhre, Renee M. Demarest, David M. Devilbiss, 2025 Hepatocyte Growth Factor MET Activator Rescues Working Memory Deficits After Repeated Mild Traumatic Brain Injury Adult Hippocampal Neurogenesis in the Human Brain: Updates, Challenges, and Perspectives Sophie Simard, Natalie Matosin, Naguib Mechawar, 2025
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dihexa neurogenesis Figure 4 — Vitamin D deficiency as a potential risk factor for accelerated aging, impaired hippocampal neurogenesis and cognitive decline: a role for Wnt/β-catenin signaling